nanos and pumilio Are Essential for Dendrite Morphogenesis in Drosophila Peripheral Neurons

نویسندگان

  • Bing Ye
  • Claudia Petritsch
  • Ira E Clark
  • Elizabeth R Gavis
  • Lily Yeh Jan
  • Yuh Nung Jan
چکیده

Much attention has focused on dendritic translational regulation of neuronal signaling and plasticity. For example, long-term memory in adult Drosophila requires Pumilio (Pum), an RNA binding protein that interacts with the RNA binding protein Nanos (Nos) to form a localized translation repression complex essential for anterior-posterior body patterning in early embryogenesis. Whether dendrite morphogenesis requires similar translational regulation is unknown. Here we report that nos and pum control the elaboration of high-order dendritic branches of class III and IV, but not class I and II, dendritic arborization (da) neurons. Analogous to their function in body patterning, nos and pum require each other to control dendrite morphogenesis, a process likely to involve translational regulation of nos itself. The control of dendrite morphogenesis by Nos/Pum, however, does not require hunchback, which is essential for body patterning. Interestingly, Nos protein is localized to RNA granules in the dendrites of da neurons, raising the possibility that the Nos/Pum translation repression complex operates in dendrites. This work serves as an entry point for future studies of dendritic translational control of dendrite morphogenesis.

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عنوان ژورنال:
  • Current Biology

دوره 14  شماره 

صفحات  -

تاریخ انتشار 2004